Interactive Fitness Landscape
Click amino acid chips, heatmap cells, or logo letters to filter. Distributions, structure, and tables update in lockstep.
Position Filters
Marginal Fitness Heatmap
Fitness Distributions
Ras–Raf Interface · 3D Structure
PDB 4G0N. Selecting a non-WT amino acid replaces the side chain with a Dunbrack rotamer so you can see steric and chemical changes at the binding site.
Atomic View
PDB 4G0N
Fitness at Interface
Raf RBD (Chain B, residues 72–96) at the Ras binding interface.
Low fitness
High fitness
Ras Contact Residues
Sequence Composition
How variants are built and how biochemistry shapes fitness.
Sequence Logo · per Position
Mean Fitness by AA Property
Variant vs Wildtype · Fitness Δ
Pairwise Epistasis
Mean fitness for each AA combination at two positions, conditioned on current filters
Sequence Explorer
Browse, search, and sort all sequences. Filters from above are applied.
| Rank | Sequence | C81 | K84 | A85 | V88 | Fitness | Tags |
|---|
Summary Statistics
Overview of the fitness landscape distribution and key metrics.